Modafinil 400mg is a high dose of the prescription drug modafinil, an aid to promote wakefulness in patients with particular sleep disorders. It is approved to treat excessive daytime sleepiness related to narcolepsy, obstructive sleep apnea, and shift work disorder. Modafinil influences activity of the central nervous system; however, the exact mechanism of the action is not known yet. Various daily doses of up to 400mg have been investigated; according to clinical data, there is no reliable evidence that 400mg offers better results than 200mg per day. In any case, the proper dose should be chosen by the doctor depending on the disease and the individual response. Possible side effects may involve headache, nausea, nervousness, anxiety, dizziness, and insomnia. Modafinil may interact with other drugs, and it reduces the effect of steroidal hormonal contraceptives, so another kind of contraceptive method should be chosen. Also, serious skin reactions, psychiatric conditions, and allergic reactions have been noted. Modafinil 400mg should be used according to the prescription only and not to substitute the sleep or treat usual fatigue.

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